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2020涂庭源

 

專任教師

姓名

職稱

學歷

專長

備註

涂庭源

助理教授

新加坡國立大學 機械生物學所 博士

細胞力學

 

  

姓名

涂庭源 (Ting-Yuan TU)

涂庭源助理教授

職稱

助理教授

辦公室

醫工系 5758C

聯絡電話

06-2757575 ext.63440 (辦公室)

傳真

06-2343270

E-Mail

tingyuan@mail.ncku.edu.tw

實驗室

整合機械生物系統實驗室

Integrated MechanoBioSystems Lab

學歷

  • 新加坡國立大學 機械生物學所 博士 2015
  • 國立台灣大學 應用力學所 碩士 2009
  • 國立台北科大學 能源與冷凍空調工程系 學士 2007

經歷

  • 助理教授, 國立成功大學 生物醫學工程學系 2016-目前
  • 應用科學家, Clearbridge Biomedics Pte Ltd 2014-2016
  • 研究助理, BioSyM,新加坡-麻省理工聯盟科技研究中心 2010-2014
  • 研究助理國立台灣大學 應用力學所 2009-2010

研究專長

  • 微流體藥物篩檢
  • 三維細胞培養
  • 腫瘤微環境
  • 體外組織模型
  • 快速成型技術

近五年榮譽與獲獎 (2016-2020)

  • MOST Young Scholar Fellowship Program, Ministry of Science and Technology, Taiwan, 2019

1st Prize Young Investigator Award, Global Conference on Biomedical Engineering (GCBME), Taoyuan, Taiwan, 2018

近五年研究成果 (2016-2020)

Google Scholar: Ting-Yuan (TY) TU

(1) Refereed Paper

2020

  1. Wu, K.-W.; Kuo, C.T.; Tu, T.-Y* A highly reproducible micro U-well array plate facilitating high-throughput tumor spheroid culture and drug assessment. Global Challenges, 2020, Accepted. (Multidisciplinary Sciences 16/71, IF=4.306)
  2. Chen, Y.-W.; Chen, M.-C.; Wu, K.-W.; Tu, T.-Y*. A Facile Approach for Rapid Prototyping of Microneedle Molds, Microwells and Micro-Through-Holes in Various Substrate Materials Using CO2 Laser Drilling. Biomedicines 2020, 8, 427. (Pharmacology & Harmacology & Pharmacy 36/270, IF=4.717)
  3. H.-C. Chuang; K.-L. Tsai; K.-J. Tsai; T.-Y. Tu; Y.-J. Shyong; I-M. Jou; C.-C. Hsu; Y.-F. Liu; C.-L. Lin*, Oxidative stress mediates age-related hypertrophy of ligamentum flavum by inducing inflammation, fibrosis, and apoptosis through activating Akt and MAPK pathways, Aging, Accepted. (Geriatrics & Gerontology 7/51, IF=4.831)
  4. C.-L. Lin; Y.-T. Kuo; C.-H Tsao; Y.-J. Shyong; S.-H. Shih; T.-Y. Tu*, Development of an In Vitro 3D Model for Investigating Ligamentum Flavum Hypertrophy, Biological Procedures Online, 22 (1), 1-12, 2020, (Biochemical Research Methods 38/77, IF=2.711)

2019

  1. Chiu, C.-Y.; Chen, Y.-C.; Wu, K.-W.; Hsu, W.-C.; Lin, H.-P.; Chang, H.-C.; Lee, Y.-C.; Wang, Y.-K.; Tu, T.-Y.* Simple In-House Fabrication of Microwells for Generating Uniform Hepatic Multicellular Cancer Aggregates and Discovering Novel Therapeutics. Materials 2019, 12, 3308. (Materials, Multidisciplinary 132/314, IF=3.057)

2018

  1. Chen, Y.C., Chiu, W.T., Chang, C., Wu, P.C., Tu, T.-Y., Lin, H.P., Chang, H.C. Chemo-photothermal effects of doxorubicin/silica-carbon hollow spheres on liver cancer. RSC Advances 8 (2018) 36775–36784. (Chemistry, Multidisciplinary 68/172, IF=3.049)

(2) Conference Paper

2020

  1. Yao-Ting Li, Hsu-Chan Kuo, Ting-Yuan Tu*, Integrating rapid fabrication of 3D printed innovative teaching aids into microfluidics course and its impact on student’s creativity and learning motivation, The 4th Global Conference on Biomedical Engineering & Annual Meeting of TSBME (GCBME 2020), Taipei, Taiwan, 2020
  2. Bo-Yu Chang, Ting-Yuan Tu*, Study on the application of microfluidics to tumor cell migration inhibiting drugs, The 4th Global Conference on Biomedical Engineering & Annual Meeting of TSBME (GCBME 2020), Taipei, Taiwan, 2020 (oral presentation)
  3. Guan-Lin Su, Ting-Yuan Tu*, Development of a Hydrogel Interface With Co-cultured HUVECs to Study the Invasion Pattern of Breast MCTS, The 4th Global Conference on Biomedical Engineering & Annual Meeting of TSBME (GCBME 2020), Taipei, Taiwan, 2020 (oral presentation)
  4. Chia-en Yang, Yan-jye Shyong, Cheng-li Lin, Ting-yuan Tu,* Investigation of LF cell aggregation in promoting myofibroblast formation in LF hypertrophy, The 4th Global Conference on Biomedical Engineering & Annual Meeting of TSBME (GCBME 2020), Taipei, Taiwan, 2020 (oral presentation)
  5. Ya-Chu Tsai, Ting-Yuan Tu*, Studying initial metastasis at the matrix interface with different matrix stiffness in microfluidics, The 4th Global Conference on Biomedical Engineering & Annual Meeting of TSBME (GCBME 2020), Taipei, Taiwan, 2020 (oral presentation)
  6. Kim Mai Nguyen, Ting-Yuan Tu*, Investigation on the effect of matrix adhesion strength in the metastatic pattern of breast multicellular tumor spheroid invasion, The 4th Global Conference on Biomedical Engineering & Annual Meeting of TSBME (GCBME 2020), Taipei, Taiwan, 2020 (oral presentation)
  7. Chien-Hsin Yu, Ting-Yuan Tu*, Quantitative investigation of the 3D spheroid model using a clearing-enhanced imaging approach, The 4th Global Conference on Biomedical Engineering & Annual Meeting of TSBME (GCBME 2020), Taipei, Taiwan, 2020 (oral presentation)
  8. Fang-Chun Liao , Ting-Yuan Tu*,  Investigation of in vitro hepatic spheroid culture in promotion of liver differentiation, The 4th Global Conference on Biomedical Engineering & Annual Meeting of TSBME (GCBME 2020), Taipei, Taiwan, 2020 (oral presentation)
  9. Yen-Ping Shen, Ting-Yuan Tu*, Generation of a smooth and circular vessel lumen using viscous fingering pattern (VFP) in AIM microfluidic chips, 2020 International Conference on Smart Sensors, Kaohsiung, Taiwan, 2020
  10.  Li Te Wei, Ting Yuan Tu*, Cheng Li Lin, Investigation on the cyclic stretching induced oxidative stress on Ligamentum Flavum cells in 3D environment, 2020 International Conference on Smart Sensors, Kaohsiung, Taiwan, 2020
  11. Yao-Ting Li, Ting-Yuan Tu*, Rapid fabrication of transparent and biocompatible 3D-printed devices for microfluidics research, 2020 International Conference on Smart Sensors, Kaohsiung, Taiwan, 2020
  12. Yao-Ting Li, Ting-Yuan Tu*, Rapid fabrication of transparent 3D-printed inertial microfluidic devices, 30th Anniversary World Congress on Biosensors, Bushan, Korea 2020 (commended poster presentation) (conference postponed)
  13. Kim Mai Nguyen, Ting-Yuan Tu*, Investigation on the effect of matrix adhesion strength in the metastatic pattern of tumor spheroid invasion, Tissue Engineering and Regenerative Medicine International Society (TERMIS) European Chapter Meeting 2020, Manchester, United Kingdom, 2020 (oral presentation) (conference postponed)

2019

  1. Yu-Wei Chen, Kuang-Wei Wu, Ting-Yuan Tu*, Rapid fabrication of arrayed microstructures for cellular-based applications, 2019 International Conference on Smart Sensors, Hsinchu, Taiwan, 2019 (oral presentation)
  2. Yen-Ping Shen, Ting-Yuan Tu*Investigation on the effect of interstitial fluid stress onThree-Dimension bladder cancer cell migration using a three-dimensional microfluidic approach, 2019 International Conference on Smart Sensors, Hsinchu, Taiwan, 2019 (oral presentation)

2018

  1. Kuang-Wei Wu, Ting-Yuan Tu*, Ultra-stable and ultra-fast fabrication of microwells using laser ablation in plane PS for the formation of size-controlled hepatic tumor spheroids, The Twenty Second International Conference on Miniaturized Systems for Chemistry and Life Sciences (µTAS 2018), Kaohsiung, Taiwan, 2018
  2. Jae-Hao Cao, Yi-Ting Guo, Shu-Hsien Shih, Ting-Yuan Tu*, Cheng-Li Lin*INVESTIGATION OF LIGAMENTUM FLAVUM HYPERTROPHY VIA CYCLIC MECHANICAL STRESS, 2018 Global Conference on Biomedical Engineering (GCBME), Taoyuan, Taiwan 2018 (oral presentation)
  3. Yi-Ting Guo, Shu-Hsien Shih, Jae-Hao Cao, Ting-Yuan Tu*, Cheng-Li Lin*Development of an in vitro 3D spheroid culture platform for investigation on the pathogenesis of ligamentum flavum hypertrophy, 2018 Global Conference on Biomedical Engineering (GCBME), Taoyuan, Taiwan 2018 (oral presentation)
  4. Kuang-Wei Wu, Ting-Yuan Tu*, Ultrastable fabrication of microwells for generation of in vitro 3D hepatic tumor model and discovery of photothermal treatment, 2018 Global Conference on Biomedical Engineering (GCBME), Taoyuan, Taiwan 2018 (oral presentation)
  5. Chiao-Yi Chiu, Ying-Chi Chen, Kuang-Wei Wu, Ting-Yuan Tu*, Rapid fabrication of size-controlled microwells for generation of in vitro 3D hepatic tumor model and discovery, The 8th World Congress on Biomechanics 2018, Dublin, Ireland, 2018

2017

  1. Kuang-Wei Wu, Zi-Ting Huang, Chiao-Yi Chiu, Ting-Yuan Tu*, FABRICATION OF SIZE-CONTROLLED CONCAVE MICROWELLS FOR LONG-TERM CULTURE OF IN VITRO 3D HEPATIC TUMOR MODEL, 2017 Taiwanese Society of Biomedical Engineering (TSBME), Taoyuan, Taiwan 2017 (oral presentation)
  2. Chiao-Yi Chiu, Ying-Chi Chen, Kuang-Wei Wu, Ting-Yuan Tu*, Rapid fabrication of size-controlled microwells for generation of in vitro 3D hepatic tumor model and discovery of therapeutic treatment, 2017 Taiwanese Society of Biomedical Engineering (TSBME), Taoyuan, Taiwan 2017 (oral presentation)

(3)碩士、博士論文改寫成論文或出版情形。

  1. 邱巧宜, 簡單製造大小可控之微孔用於培養均勻體外多細胞腫瘤球狀體與開發新的治療方式, 國立成功大學生物醫學工程研究所, 碩士論文, 民國106
  2. 許文乾, 建構三維腫瘤與巨噬細胞微環境系統並評估氧化鐵奈米粒子對調控微環境的影響, 國立成功大學生物醫學工程研究所, 碩士論文, 民國107 (與吳炳慶老師共同指導)
  3. 郭怡婷, 建立體外三維培養模型應用於黃韌帶肥厚之研究, 國立成功大學生物醫學工程研究所, 碩士論文, 民國107 (與林政立醫師共同指導)
  4. 陳昱為, 雷射燒蝕微結構加工於不同具生物相容性基材之各式後續應用, 國立成功大學生物醫學工程研究所, 碩士論文, 民國107
  5. 曹哲豪, 探討多維循環機械拉伸對黃韌帶細胞之影響, 國立成功大學生物醫學工程研究所, 碩士論文, 民國107, (與林政立醫師共同指導)
  6. 巫光偉, 建構具高度重複之微孔陣列平台於高通量腫瘤球體培養和藥物評估之研究, 國立成功大學生物醫學工程研究所, 碩士論文, 民國108
  7. 沈彥平, 利用viscous fingering patternAIM微流體晶片產生光滑與環形之血管, 國立成功大學生物醫學工程研究所, 碩士論文, 民國108
  8. 李耀庭, 利用3D列印快速製造創新教具導入微流體課程對學生之學習動機與創造力之研究, 國立成功大學生物醫學工程研究所, 碩士論文, 民國108
  9. 阮氏金梅, 基質貼附強度對腫瘤細胞球轉移之影響 , 國立成功大學生物醫學工程研究所, 碩士論文, 民國108

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