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個人資訊(邱文泰)

專任教師

姓名

職稱

學歷

專長

備註

邱文泰

教授

國立成功大學
基礎醫學博士

鈣離子訊息

活細胞分子造影

光遺傳學

癌症抗化性與轉移

本所專任

姓名

邱文泰

邱文泰教授

職稱

教授

辦公室

成杏校區 醫工大樓二樓5758D室

聯絡電話

06-2757575-63435

傳真

06-2343270

E-Mail

wtchiu@mail.ncku.edu.tw

實驗室

細胞訊息與分子影像實驗室

學歷

國立成功大學 生科系 學士, 1993-1997
國立成功大學 生理所 碩士, 1997-1999
國立成功大學 基礎醫學所 博士, 2002-2007

經歷

日本北海道大學 獎助訪問學者 2007
國立成功大學 腫瘤中心 博士後研究員2007~2008
美國德州大學 安德森癌症中心 博士後研究員 2008~2010

成功大學附設醫院癌症中心 助理研究員 2010~2012
國立成功大學 醫工系 助理教授 2012~2016

國立成功大學 醫工系 副教授 2016~2020

國立成功大學 醫工系 教授 2020~迄今

研究專長

鈣離子訊息

活細胞分子造影

光遺傳學

癌症抗化性與轉移

近五年榮譽與獲獎 (2016-2021)

個人:

1. 104學年度國立成功大學生物醫學工程學系輔導優良教師 (Mar 2016)。

2. 104學年度國立成功大學工學院研究優良教師(Apr 2016)。

3. 105學年度國立成功大學生物醫學工程學系教學優良教師(Mar 2017)。

4. 105學年度國立成功大學教學優良教師(Aug 2017)。

5. 107學年度國立成功大學教學優良教師(Aug 2019)。

學生:

1. 指導大學生沈珍安同學與吳建緯同學獲得【105年度大專學生研究計畫】 (May 2016)。

2. 指導大學生洪嘉琳同學獲得【2016國立成功大學生物醫學工程學系大學部專題成果展覽暨競賽】佳作獎 (Oct 2016)。

3. 指導大學生沈珍安同學獲得【2016細胞動力學研討會】壁報佳作獎 (Oct 2016)。

4. 指導台南一中陳俊鴻、黃鈞郅、黃亮鈞同學獲得【2017臺灣國際科學展覽會】四等獎 (Feb 2017)。

5. 指導碩士班研究生賴怡旬同學及陳永裕同學獲得【2018細胞動力學研討會】壁報佳作獎 (May 2018)。

6. 指導碩士班研究生廖偉翔同學獲得【2019第34屆生物醫學聯合學術年會】壁報佳作獎 (Sep 2019)。

近五年著作與專利 (2016-2021)

期刊論文:

  1. Lai, Y.S., Chang, Y.H., Chen, Y.Y., Xu, J., Yu, C.S., Chang, S.J., Chen, P.S., Tsai, S.J. and Chiu, W.T.* (2021 Jun) Ca2+-regulated cell migration revealed by optogenetically engineered Ca2+ oscillations. J Cell Physiol 236(6):4681-4693. (SCI, IF=5.546; R/C=7/81, 8.64%, Physiology)
  2. Pham, T.T.H., Huang, W.Y., Chen, C.S., Chiu, W.T. and Chuang, H.S.* (2021 Jan) Effects of electrotactic exercise and antioxidant EUK-134 on oxidative stress relief in Caenorhabditis elegans. PLoS ONE 13(8):e0245474. (SCI, IF=2.740; R/C=27/71, 38.03%, Multidisciplinary Sciences)
  3. Shiu, J.L., Wu, C.K., Chang, S.B., Sun, Y.J., Chen, Y.J., Lai, C.C., Chiu, W.T., Chang, W.T., Myung, K., Su, W.P., Liaw, H.* (2020 Dec) The HLTF-PARP1 interaction in the progression and stability of damaged replication forks caused by methyl methanesulfonate. Oncogenesis 9(12):104. (SCI, IF=6.119; R/C=38/244, 15.57%, Oncology)
  4. Huang, C.L.*, Lian, M.J., Wu, Y.H., Chen, W.M., and Chiu, W.T. (2020 June) Identification of human ovarian adenocarcinoma cells with cisplatin-resistance by feature extraction of gray level co-occurrence matrix. Diagnostics 10(6):E389. (SCI, IF=2.941; R/C=39/165, 23.64%, Medicine, General & Internal)
  5. Chen, P.S., Chiu, W.T., Hsu, P.L., Lin, S.C., Peng, I.C., Wang, C.Y. and Tsai, S.J.* (2020 May) Pathophysiological implications of hypoxia in human diseases. J Biomed Sci 27(1):63. (SCI, IF=5.762; R/C=17/138, 12.32%, Medicine, Research & Experimental)
  6. Wang, C.A., Chang, I.H., Chang, H.A., Hou, P.C., Tai, Y.J., Li, W.N., Hsu, P.L., Wu, S.R., Chiu, W.T., Li, C.F., Shan, Y.S. and Tsai, S.J.* (2020 Apr) DUSP2 regulates extracellular vesicle-VEGF-C secretion and pancreatic cancer early dissemination. J Extracell Vesicles 9(1):1746529. (SCI, IF=14.98; R/C=12/195, 6.15%, Cell Biology)
  7. Huang, H.K., Lin, Y.H., Chang, H.A., Lai, Y.S., Chen, Y.C., Huang, S.C., Chou, C.Y. and Chiu, W.T.* (2020 Feb) Chemoresistant ovarian cancer enhances its migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions. J Biomed Sci 27(1):36. (SCI, IF=5.762; R/C=17/138, 12.32%, Medicine, Research & Experimental)
  8. Chiu, W.T., Vi Tran, T.T., Pan, S.C., Huang, H.K., Chen, Y.C. and Wong, T.W.* (2019 Oct) Cystic fibrosis transmembrane conductance regulator: a possible new target for photodynamic therapy enhances wound healing. Adv Wound Care 8(10):476-486. (SCI, IF=2.813; R/C=22/68, 32.35%, Dermatology)
  9. Lee, G.H., Chang, C.L., Chiu, W.T., Hsiao, T.H., Chen, P.Y., Wang, K.C., Kuo, C.H., Chen, B.H., Shi, G.Y., Wu H.L. and Fu, T.F.* (2019 Aug) A thrombomodulin-like gene is crucial to the collective migration of epibolic blastomeres during germ layer formation and organogenesis in zebrafish. J Biomed Sci 26(1):60. (SCI, IF=5.762; R/C=17/138, 12.32%, Medicine, Research & Experimental)
  10. Wong, T.W., Kan C.D., Chiu, W.T., Fok, K.L., Ruan, Y.C., Jiang, X., Chen, J., Kao, C.C., Chen, I.U., Lin, H.C., Chou, C.H., Lin, C.W., Yu, C.K., Tsao, S., Lee, Y.P., Chan, H.C. and Wang, J.N.* (2019 Jul) Progenitor cells derived from drain waste product of open-heart surgery in children. J Clin Med 8(7):E1028. (SCI, IF=3.303; R/C=36/165, 21.82%, Medicine, General & Internal)
  11. Yang, C.Y., Chang, P.W., Hsu, W.H., Chang, H.C., Chen, C.L., Lai, C.C.*, Chiu, W.T.* and Chen, H.C.* (2019 May) Src and SHP2 coordinately regulate the dynamics and organization of vimentin filaments during cell migration. Oncogene 38(21):4075-4094. (SCI, IF=7.971; R/C=14/177, 7.91%, Genetics & Heredity)
  12. Lin,Y.M., Sun, H.Y., Chiu, W.T., Su, H.C., Chien, Y.C., Chang, H.A., Chong, L.W., Chang, H.C., Young, K.C., Bai, C.H. and Tsao, C.W.* (2019 Mar) Etifoxine, a TSPO ligand, worsens hepatitis C-related insulin resistance but relieves lipid accumulation. Biomed Res Int 3102414. (SCI, IF=2.276; R/C=92/165, 55.76%, Biotechnology & Applied Microbiology)
  13. Chang, Y.J., Lo, Y.L.*, Chiu, W.T.*, Huang, C.L., Chang, H.A. and Phan, Q.H. (2018 Dec) Scanned laser pico projection and Stokes-Mueller matrix imaging polarimetry for detecting cancer cells with different cytoskeletal organizations and metastatic potencies. IEEE Photonics J 10(6):3901612. (SCI, IF=2.729; R/C=50/148, 33.78%, Physics, Applied)
  14. Chen, Y.C., Chiu, W.T.*, Chang, C., Wu, P.C., Tu, T.Y., Lin, H.P.* and Chang, H.C.* (2018 Oct) Chemo-photothermal effects of doxorubicin/silica-carbon hollow spheres on liver cancer. RSC Adv 8:36775-36784. (SCI, IF=3.049; R/C=68/172, 39.53%, Chemistry, Multidisciplinary)
  15. Wu, C.W., Chiu, W.T., Hsieh, T.H., Hsieh, C.H. and Chen, J.J.* (2018 Aug) Modulation of motor excitability by cortical optogenetic theta burst stimulation. PLoS ONE 13(8):e0203333. (SCI, IF=2.776; R/C=24/69, 34.78%, Multidisciplinary Sciences)
  16. Huang, T.Y., Lin, Y.H., Chang, H.A., Yeh, T.Y., Chang, Y.H., Chen, Y.F., Chen, Y.C., Li, C.C. and Chiu, W.T.* (2018 Jun) STIM1 knockout enhances PDGF-mediated Ca2+ signaling through upregulation of the PDGFR-PLCg-STIM2 cascade. Int J Mol Sci 19(6):1799. (SCI, IF=4.183; R/C=78/299, 26.09%, Biochemistry & Molecular Biology)
  17. Lin, H.K., Lin, H.H., Chiou, Y.W., Wu, C.L., Chiu, W.T. and Tang, M.J.* (2018 May) Caveolin-1 downregulation is required for Wnt5a-Frizzled 2 signaling in Ha-RasV12-induced cell transformation. J Cell Mol Med 22:2631-2643. (SCI, IF=4.658; R/C=31/136, 22.77%, Medicine, Research & Experimental)
  18. Chiu, W.T.*, Chang, H.A., Lin, Y.H., Lin, Y.S., Chang, H.T., Lin, H.H., Huang, H.S., Tang, M.J. and Shen, M.R. (2018 Feb) Bcl-2 regulates store-operated Ca2+ entry to modulate ER stress-induced apoptosis. Cell Death Discov 4:37. (SCI, IF=4.114; R/C=76/195, 38.97%, Cell Biology)
  19. Lin, Y.M., Sun, H.Y., Chiu, W.T., Su, H.C., Chien, Y.C., Chong, L.W., Chang, H.C., Bai, C.H., Young, K.C. and Tsao, C.W.* (2018 Jan) Calcitriol inhibits HCV infection via blockade of activation of PPAR and interference with endoplasmic reticulum-associated degradation. Viruses 10:E57. (SCI, IF=3.811; R/C=11/36, 30.56%, Virology)
  20. Kuo, S.L., Chen, C.L., Pan, Y.R., Chiu, W.T. and Chen, H.C.* (2018 Jan) Biogenesis of podosome rosettes through fission. Sci Rep 8(1):524. (SCI, IF=4.011; R/C=15/69, 21.74%, Multidisciplinary Sciences)
  21. Chen, Y.C., Chang, Y.C., Chang, H.A., Lin, Y.S., Tsao, C.W., Shen, M.R. and Chiu, W.T.* (2017 Nov) Differential Ca2+ mobilization and mast cell degranulation by FcεRI- and GPCR-mediated signaling. Cell Calcium 67:31-39. (SCI, IF=3.718; R/C=80/190, 42.11%, Cell Biology)
  22. Chen, Y.W., Lai, C.S., Chen, Y.F., Chiu, W.T., Chen, H.C. and Shen, M.R.* (2017 Sep) STIM1-dependent Ca2+ signaling regulates podosome formation to facilitate cancer cell invasion. Sci Rep 7(1):11523. (SCI, IF=4.122; R/C=12/64, 18.75%, Multidisciplinary Sciences)
  23. Li, W.P., Su, C.H., Wang, S.J., Tsai, F.J., Chang, C.T., Liao, M.C., Yu, C.C., Vi Tran, T.T., Lee, C.N., Chiu, W.T., Wong, T.W. and Yeh, C.S.* (2017 Jun) CO2 delivery to accelerate incisional wound healing following single irradiation of near-infrared lamp on the coordinated colloids. ACS Nano 11:5826-5835. (SCI, IF=13.709; R/C=12/285, 4.21%, Material Science, Multidisciplinary)
  24. Su, W.P., Ho, Y.C., Wu, C.K., Hsu, S.H., Shiu, J.L., Chang, S.B., Chiu, W.T., Hung, J.J., Liu, T.L., Wu, W.S., Wu, P.Y., Su, W.C., Chang, J.Y. and Liaw, H.* (2017 Jun) Chronic treatment with cisplatin induces chemoresistance through the TIP60-mediated Fanconi anemia and homologous recombination repair pathways. Sci Rep 7(1):3879. (SCI, IF=4.122; R/C=12/64, 18.75%, Multidisciplinary Sciences)
  25. Huang, H.T., Liao, C.K., Chiu, W.T. and Tzeng, S.F.* (2017 Mar) Ligands of peroxisome proliferator-activated receptor-alpha promote glutamate transporter-1 endocytosis in astrocytes. Int J Biochem Cell Biol 86:42-53. (SCI, IF=3.247; R/C=118/293, 40.27%, Biochemistry & Molecular Biology)
  26. Chang, S.J., Chen, Y.C., Yang, C.H., Huang, S.C., Huang, H.K., Li, C.C., Harn, H.I. and Chiu, W.T.* (2017 Mar) Revealing the three dimensional architecture of focal adhesion components to explain Ca2+-mediated turnover of focal adhesions. BBA-Gen Subjects 1861(3):624-635. (SCI, IF=3.679; R/C=16/72, 22.22%, Biophysics)
  27. Lin, Y.M., Yu, B.C., Chiu, W.T., Sun, H.Y., Chien, Y.C., Su, H.C., Yen, S.Y., Lai, H.W., Bai, C.H., Young, K.C. and Tsao, C.W.* (2016 Oct) Fluoxetine regulates cell growth inhibition of interferon-α. Int J Oncol 49(6):1746-1754. (SCI, IF=3.079; R/C=105/217, 48.39%, Oncology)
  28. Yen, T.T., Yang, A., Chiu, W.T., Li, T.N., Wang, L.H., Wu, Y.H., Wang, H.C., Chen, L., Wang, W.C., Huang, W., Chang, C.W., Chang, M.D., Shen, M.R., Su, I.J. and Wang, L.H.* (2016 Mar) Hepatitis B virus preS2-mutant large surface antigen activates store-operated calcium entry and promotes chromosome instability. Oncotarget 7(17):23346-23360. (SCI, IF=5.168; R/C=44/217, 20.28%, Oncology)
  29. Harn, H.I., Hsu, C.K., Wang, Y.K., Huang, Y.W., Ho, Y.T., Chiu, W.T., Lin, H.H., Cheng, C.M. and Tang, M.J.* (2016 Feb) Spatial distribution of filament elasticity determines the migratory behaviors of a cell. Cell Adh Migr 26:1-10. (SCI, IF=3.872; R/C=75/190, 39.47%, Cell Biology)
  30. Chen, Y.W., Chen, Y.F., Chen, Y.T., Chiu, W.T. and Shen, M.R.* (2016 Feb) The STIM1-Orai1 pathway of store-operated Ca2+ entry controls the checkpoint in cell cycle G1/S transition. Sci Rep 6:22142. (SCI, IF=4.259; R/C=10/64, 15.63 %, Multidisciplinary Sciences)

會議論文:

  1. Liao, W.H., Chiu, W.T. The modulatory role of caveolin-1 in crosstalk between TGF-β and EGF signaling pathways. The 27th Symposium on Recent Advances in Cellular and Molecular Biology. February 5-February 7, 2020. Pingtung, Taiwan. (Poster presentation)
  2. Chang, C.C., Chiu, W.T. Modulation of mitochondrial morphological transition by optogenetically engineered Ca2+. The 27th Symposium on Recent Advances in Cellular and Molecular Biology. February 5-February 7, 2020. Pingtung, Taiwan. (Poster presentation)
  3. Chiu, W.T., Huang, H.K., and Lin, Y.H. Chemoresistant ovarian cancer possesses higher migration abilities by increasing store-operated Ca2+ entry-mediated turnover of focal adhesions. Goodbye Flat Biology: Advancing 3D-based Models for Cancer Biology and Drug Discovery. November 10-November 13, 2019. Berlin, Germany. (Poster presentation)
  4. Lin, Y.S., Huang, W.H., and Chiu, W.T. Targeting endocannabinoid system to reverse chemoresistance ovarian cancer. International Congress on Clinical Trials in Cannabis (CT-Cann2019). October 24-October 25, 2019. London, England. (Poster presentation)
  5. Chiu, W.T., Chang, Y.H., and Lai, Y.S. Optogenetics-mediated Ca2+ signaling in regulation of Ca2+-dependent transcription factor activation. 2nd International Translational and Regenerative Medicine Conference. April 15-April 16, 2019. Valencia, Spain. (Poster presentation)
  6. Chin, L.C. and Chiu, W.T. Effect of STMI1 activity on ER stress-mediated apoptosis. 2019 The 34th Joint Annual Conference of Biomedical Science. March 23-March 24, 2019. Taipei, Taiwan. (Poster presentation)
  7. Lin, Y.H. and Chiu, W.T. Store-operated Ca2+ entry regulates the dynamic of focal adhesions. 2019 The 34th Joint Annual Conference of Biomedical Science. March 23-March 24, 2019. Taipei, Taiwan. (Poster presentation)
  8. Liao, W.H. and Chiu, W.T. The modulatory role of caveolin-1 in TGF-β signaling pathways. 2019 The 34th Joint Annual Conference of Biomedical Science. March 23-March 24, 2019. Taipei, Taiwan. (Poster presentation)
  9. Shen, C.A. and Chiu, W.T. The role of Ca2+ in the regulation of an oncogenic transcription factor forkhead box M1 (FOXM1) in ovarian cancer. 2019 The 34th Joint Annual Conference of Biomedical Science. March 23-March 24, 2019. Taipei, Taiwan. (Poster presentation)
  10. Chen, Y.Y., Huang, P.H., Chang, Y.T. and Chiu, W.T. The effect of Ca2+ oscillations on the regulation of mitochondrial function by optogenetics. 2018 Cell Dynamics Conference-NCKU-NUS bilateral conference. May 28-May 29, 2018. Tainan, Taiwan. (Poster presentation)
  11. Lai, Y.S., Chang, Y.H. and Chiu, W.T. Activation of Ca2+-dependent transcription factors by optogenetic engineered Ca2+ oscillations. 2018 Cell Dynamics Conference-NCKU-NUS bilateral conference. May 28-May 29, 2018. Tainan, Taiwan. (Poster presentation)
  12. Chiu, W.T., Chang, Y.H., Yu, C.S. and Lai, Y.S. Decoding Ca2+ signaling in regulation of transcription factor activation and cell cycle progression using optogenetics. International Translational and Regenerative Medicine. April 25-April 27, 2018. Roma, Italy. (Poster presentation)
  13. Xu, J.X., Chang, Y.A. and Chiu, W.T. Effect of caveolin-1 on podosome formation. 2018 The 33th Joint Annual Conference of Biomedical Science. March 24-March 25, 2018. Taipei, Taiwan. (Poster presentation)
  14. Chen, Y.Y., Huang, P.H., Chang, Y.T. and Chiu, W.T. The effect of Ca2+ oscillations on the regulation of mitochondrial function by optogenetics. 2018 The 33th Joint Annual Conference of Biomedical Science. March 24-March 25, 2018. Taipei, Taiwan. (Poster presentation)
  15. Lai, Y.S., Chang, Y.H. and Chiu, W.T. Activation of Ca2+-dependent transcription factors by optogenetic engineered Ca2+ oscillations. 2018 The 33th Joint Annual Conference of Biomedical Science. March 24-March 25, 2018. Taipei, Taiwan. (Poster presentation)
  16. Wu, Y.H., Lian, M.J., Huang, C.L. and Chiu, W.T. Scanned laser pico-projection image processing for cancer-like cells induced by isopropyl β-D-1-thiogalactopyranoside. 2018 International Conference on Smart Materials Applications (ICSMA 2018). Jan 26-28, 2018. Singapore. (Oral presentation)
  17. Chen, Y.C., Chiu, W.T., Lin, H.P. and Chang, H.C. The chemo-photothermal effect of doxorubicin/silica-carbon hollow spheres. 2017 International Symposium on Smart-Sensing Medical Devices and 22nd Symposium of Association for Chemical Sensors in Taiwan (2017 ISSMD and 22nd SACST). May 20, 2017. Tainan, Taiwan. (Poster presentation)
  18. Yu, C.S., Shen, C.A., Chang, Y.H. and Chiu, W.T. Optogenetic engineering of intracellular Ca2+ oscillations in regulation of nuclear lamin dynamics and mitotics progression. 2017 The 32th Joint Annual Conference of Biomedical Science. March 25-March 26, 2017. Taipei, Taiwan. (Poster presentation)
  19. Chiu, W.T., Huang, Y.F., Tsai, H.Y. and Chou, C.Y. (March 13-March 16, 2017) FOXM1 confers to epithelial-mesenchymal transition, stemness and chemoresistance in epithelial ovarian carcinoma cells. Making it Personal: Cancer Precision Medicine. Amsterdam, Netherlands. (Poster presentation)
  20. Chen, Y.C., Chiu, W.T., Lin, H.P. and Chang, H.C. The chemo-photothermal effect of doxorubicin/silica–carbon hollow spheres. 2016臨床工程研討會暨醫工學會會員大會. November 11, 2016. Hsinchu, Taiwan. (Poster presentation)
  21. Shen, C.A., Yu, C.S. and Chiu, W.T. Optogenetic engineering of nuclear Ca2+ oscillations in regulation of cell cycle progression and mitotic spindle dynamics. 2016 Cell Dynamics-Molecular Development and Metabolism. October 25, 2016. Tainan, Taiwan. (Poster presentation)
  22. Huang, H.K., Chen, Y.C. and Chiu, W.T. Stored-operated Ca2+ entry confers to higher focal adhesion dynamics and migration abilities in chemoresistant ovarian cancer cells. 2016 Cell Dynamics-Molecular Development and Metabolism. October 25, 2016. Tainan, Taiwan. (Poster presentation)
  23. Chiu, W.T. Manipulation of Ca2+-dependent transcription factor activation and cell cycle progression using optogenetics. 2016 Biomedical Engineering Ecosystem Symposium. October 5-October 7, 2016. Tainan, Taiwan. (Oral presentation)
  24. Chiu, W.T. and Chang, Y.C. The in vitro real time recording of Ca2+ mobilization and histamine degranulation by TIRFM in living single mast cell. 2016 World Molecular Imaging Congress (WMIC). September 7-Septemberh 10, 2016. New York, USA. (Poster presentation)
  25. Huang, H.K., Chen, Y.C. and Chiu, W.T. Enhancement of migration ability in chemoresistant cells by regulating focal adhesion dynamics. 2nd Global Conference on Biomedical Engineering, GCBME 2016. August 17-August 19, 2016. Taipei, Taiwan. (Oral presentation)
  26. Chiu, W.T. and Chang, Y.C. Real time recording of Ca2+ mobilization and histamine degranulation in living single mast cell. Global Conference on Life Science & Biological Engineering. March 29-March 31, 2016. Kyoto, Japan. (Oral presentation)

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